Chronic sleep restriction (CSR) has been implicated in higher risk of insulin resistance (IR) and immune-metabolic dysfunction. No studies investigated the effect of CSR on macrophage differentiation in vWAT in relation to leptin synthesis and glucose homeostasis. Therefore, this study aimed at assessing blood glucose levels and vWAT expression of leptin, CD38, and CD163 following CSR. Adult male C57BL/6 mice were housed under 12:12 L/D cycle (lights on at 0700 hrs) with free access to food. Following a two-week acclimatization period, animals were divided into 2 groups: 1) control (C, N=8) ...