Background – Increasing prevalence of overweight and obesity is a major worldwide problem associated with many metabolic abnormalities. Compliance is poor with lifestyle modifications required for losing weight and maintaining long-term weight loss. There are no highly efficacious and safe therapeutic drugs for weight-loss, and few medications are approved for long-term management of obesity. In recent years, the use of supplements for weight loss has steadily increased among US and European adults. Weight loss supplements are easily available without prescriptions and do not require strict ...