The anti-tumor effects of curcumin on the p53 pathway of human endometrial carcinoma cells

Abstract

One of the clinically major gynecological cancers is endometrial carcinoma that develops from the lining of the uterus. During the past years, different approaches have been developed to treat endometrial carcinoma, among which natural herbal medicine has recently faired as an effective method. The yellow Indian spice known as curcumin has been extolled for its healing powers and has recently been adopted for investigation by the scientific community as a potent anti-cancerous agent. Curcumin possesses anticancerous effects by targeting several important players in cell signaling pathways such as Ras, MAPKs, ERK, Wnt-β, PI3K Akt, and p53.This paper highlights all studies pertaining to curcumin and its effect on endometrial cancer, but no study was found to demonstrate the effect of curcumin on the p53 pathway of endometrial cancer cells. This study aims to show how curcumin affects endometrial cancer through targeting the p53