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Browsing Theses and Dissertations by Title

Browsing Theses and Dissertations by Title

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  • Rhaim, Zeina Antoine (Notre Dame University-Louaize, 2019)
    Known as polymorphonuclear leukocytes (PMNs), neutrophils have been shown to play a regulatory role in healing injuries and resolving infections. Although the immune response (IR) of neutrophils in bacterial and fungal infections is well understood, their impact during sporozoite infection is much less studied. This project investigates the role of neutrophils in recognizing Plasmodium berghei sporozoites in an effort to understand the mechanism of sporozoites’ IR evasion and spread of malaria infection in the blood circulation. Plasmodium berghei GFP-expressing sporozoites were purified from ...
  • Nassar, Marc Gerges (Notre Dame University-Louaize., 2020)
    The HPG axis interacts with the Sertoli and Leydig cells to ensure the proper functioning of the male reproductive system. Environmental insults, which are becoming increasingly more common, affect the sensitive male reproductive system in harmful ways. Therefore, the aim of this thesis was to, analyze a network of the paternally imprinted infertility genes shared between the HPG axis and the Sertoli and Leydig cells. With this network in place, we aimed to develop a cell culture system that would allow the evaluation of the effects of certain environmental contaminants such as mycotoxins on ...
  • Nader, Ingrid (Notre Dame University-Louaize, 2021)
    Candida albicans, is usually a harmless fungus in healthy individuals, but life-threatening when found in large quantities or in inappropriate parts of the body. It developed resistance against the antifungal drugs fluconazole and amphotericin B, used in an abusive way, by adopting different mechanisms. Medicinal plants, which offer a wide variety of secondary metabolites, especially saponins, have been reported for their large biological activities. These phytochemicals are composed of a hydrophobic part (aglycone) and a hydrophilic one (glycone), which, based on their aglycone part, are ...
  • Ghosn, Marc (Notre Dame University-Louaize, 2020-07)
    An extraction protocol for saponins of Styrax Officinalis plant was adopted, modified and successfully applied. The extract obtained was tested by stabilizing Oil-in-Water emulsions. Ethanol extraction and successful one-step partial purification using AB-8 adsorption column chromatography yielded positive colorimetric (Vanillin – Sulfuric Acid) TLC results. The 3D structure of the four Styrax Officinalis saponins reported in the literature were rendered for the first time, and their partitioning properties exclusively acquired using Marvin Sketch chemical drawing software. 10% w/w Sunflower Oil ...
  • Boukarroum, Rayyan Hamad (Notre Dame University-Louaize, 2020)
    Cement is one of the most fundamentally used material all over the world. Among the many different properties of cement, compressive strength conventionally determined at the age of 28 days remains the most important parameter to assess cement quality. Waiting for 28 days to obtain a test result urges cement manufacturers to set quality parameters higher than the minimum accepted by norms, which means higher unnecessary manufacturing costs. The aim of this study is to assess the performance of cement mortar when nano silica (Nano-SiO2) is used as supplementary cementitious material (SCMs) and ...
  • Dib, Kevin (Notre Dame University-Louaize, 2020-10)
    In this work, Silver Nanoparticles (AgNPs) were synthesized in water using either polymer assisted chemical reduction synthesis method or green synthesis. The obtained AgNPs were characterized by Dynamic Light Scattering (DLS) and UV-visible spectroscopy (UV-vis), and further tested for antibacterial activity to evaluate their potential use in wound healing. At first polyvinylpyrrolidone (PVP 10 KD) and Low-Molecular Weight Chitosan were used as coating agents during the reduction of silver nitrate with a strong reducing agent sodium borohydride (NaBH4). Our DLS results demonstrated that ...
  • Mitri, Nadim (Notre Dame University-Louaize, 2020)
    In this study, gold nanoparticles (AuNPs) were synthesized in water and characterized using ultraviolet-visible spectroscopy (UV-Vis), dynamic light scattering (DLS) and Zeta potential analysis. AuNPs were coated with thiol functionalized polyethylene glycol (PEG-SH) and scFvD2B (antibody fragment of D2B mAb) well known to recognize the extracellular epitope of the human prostate specific membrane antigen (hPSMA). In fact, scFvD2B binds PSMA and induces its endocytosis, thereby marking PSMA as a docking site for the delivery of therapeutic agents. AuNPs successful coating was confirmed by DLS ...
  • Ismail, Diana (Notre Dame University-Louaize, 2019-02)
    In this thesis, we have restudied a sample chosen by (Lusso & Risaliti, 2016) consisting of a set of 2,153 unique quasars given by two source catalogues: 3XMM-DR5 (Rosen et al., 2016) and DR7 catalogue (Shen et al., 2011). Quasars serve science in two different ways: 1) Understanding accretion physics by studying the physical mechanism occuring between the disk and cloud corona, and 2) they are good cosmological probes in distance estimation reaching redshifts ~ 7 (Mortlock et al., 2011). A physical relation has been observed between the optical-UV disk and the X-ray corona through a log-log ...

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