Candida albicans, is usually a harmless fungus in healthy individuals, but life-threatening when found in large quantities or in inappropriate parts of the body. It developed resistance against the antifungal drugs fluconazole and amphotericin B, used in an abusive way, by adopting different mechanisms. Medicinal plants, which offer a wide variety of secondary metabolites, especially saponins, have been reported for their large biological activities. These phytochemicals are composed of a hydrophobic part (aglycone) and a hydrophilic one (glycone), which, based on their aglycone part, are ...

Antibiotic resistance and prevalence of hospital (HAI) and community-acquired (CAI) infections are significantly increasing in the world, though very few studies are addressing this topic in Lebanon. Therefore, this meta-analysis aims to identify antibiotic (AB) resistance prevalence among hospital and community acquired infections. Literature databases were searched for antibiotic resistance, HAI, and CAI in Lebanon from 2010 to 2020. To be eligible for inclusion, studies had to report data in Lebanon published between 2010 and 2020, antibiotic resistance in microorganisms responsible for either ...

Abrupt work schedules, such as nightshifts, are prevalent nowadays and are known to cause circadian misalignment and sleep disruption which can have adverse health consequences. Among the well documented pathologies among night workers are cardiometabolic impairments, the effects of which appear to be more disruptive in older adults due to their poorer adaptation to night work schedules. The physiological mechanisms by which night shift work and sleep disruption contribute to increased cardiovascular disease (CVD) risk are poorly understood. Furthermore, the potential role of specific CVD ...

Vaccination is a preventive measure to reduce death and morbidity against infectious diseases, and has been applied effectively against most of the viral and bacterial infections around the world. Targeted campaigns against children diseases have been very effective in drastically reducing such diseases thanks to national immunization programs in both developed and developing countries. However, many individuals including parents of various ages are still reluctant to commit to vaccination and some recent fears have been increasing when it comes to vaccination more recently, especially due to ...

Chronic sleep restriction (CSR) has been implicated in higher risk of insulin resistance (IR) and immune-metabolic dysfunction. No studies investigated the effect of CSR on macrophage differentiation in vWAT in relation to leptin synthesis and glucose homeostasis. Therefore, this study aimed at assessing blood glucose levels and vWAT expression of leptin, CD38, and CD163 following CSR. Adult male C57BL/6 mice were housed under 12:12 L/D cycle (lights on at 0700 hrs) with free access to food. Following a two-week acclimatization period, animals were divided into 2 groups: 1) control (C, N=8) ...