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Browsing Theses and Dissertations by Author "Kabrita-Bou Serhal, Colette, Ph.D."

Browsing Theses and Dissertations by Author "Kabrita-Bou Serhal, Colette, Ph.D."

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  • Altered macrophage differentiation and leptin expression in visceral white adipose tissue following chronic sleep restriction in mice 
    Shaabo, Layal (Notre Dame University-Louaize, 2022-05)
    Chronic sleep restriction (CSR) has been implicated in higher risk of insulin resistance (IR) and immune-metabolic dysfunction. No studies investigated the effect of CSR on macrophage differentiation in vWAT in relation to leptin synthesis and glucose homeostasis. Therefore, this study aimed at assessing blood glucose levels and vWAT expression of leptin, CD38, and CD163 following CSR. Adult male C57BL/6 mice were housed under 12:12 L/D cycle (lights on at 0700 hrs) with free access to food. Following a two-week acclimatization period, animals were divided into 2 groups: 1) control (C, N=8) ...
  • Effect of acute sleep restriction on the concentration of serum soluble leptin receptor in healthy adult females 
    Azzi, Elissar Elias (Notre Dame University-Louaize, 2018-06)
    Sleep restriction is now considered to be a worldwide epidemic, as over 20% of people around the world are sleep deprived. Although sleep deprivation is now an overlooked feature of modern societies, it entails considerable adverse effects on physiological systems, one being energy homeostasis. A corpus of research has demonstrated that leptin, a key hormone that conveys the body's energy status to the brain, decreases after sleep restriction, which may partly account for the associated alteration in body metabolism; however little information is available regarding the underlying ...
  • The impact of circadian misalignment and inadequate sleep duration on cardiovascular health in older adults : what can we learn from night shift workers? 
    El Hayek Bou Mansour, Michella (Notre Dame University-Louaize, 2021-12)
    Abrupt work schedules, such as nightshifts, are prevalent nowadays and are known to cause circadian misalignment and sleep disruption which can have adverse health consequences. Among the well documented pathologies among night workers are cardiometabolic impairments, the effects of which appear to be more disruptive in older adults due to their poorer adaptation to night work schedules. The physiological mechanisms by which night shift work and sleep disruption contribute to increased cardiovascular disease (CVD) risk are poorly understood. Furthermore, the potential role of specific CVD ...

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