Prostate cancer (PCa) is the most frequent cancer malignancy among men and the third leading cause of cancer death in the developed world. To date, the exact molecular mechanism underlying the role of caffeine one of the major coffee constituents on PCa prognosis is not yet unraveled. Caffeine has many antioxidant, anti-inflammatory and anti carcinogenic properties through the modulation of certain inflammatory markers such as IL-6 and TNF-α. The present study was carried out to evaluate the effect of caffeine on PCa cell lines viability, namely PC3 and PC3-PSMA and assessing as well their ...