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Browsing Theses and Dissertations by Issue Date

Browsing Theses and Dissertations by Issue Date

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  • Rhaim, Zeina Antoine (Notre Dame University-Louaize, 2019)
    Known as polymorphonuclear leukocytes (PMNs), neutrophils have been shown to play a regulatory role in healing injuries and resolving infections. Although the immune response (IR) of neutrophils in bacterial and fungal infections is well understood, their impact during sporozoite infection is much less studied. This project investigates the role of neutrophils in recognizing Plasmodium berghei sporozoites in an effort to understand the mechanism of sporozoites’ IR evasion and spread of malaria infection in the blood circulation. Plasmodium berghei GFP-expressing sporozoites were purified from ...
  • Fayjaloun, Salma (Notre Dame University-Louaize, 2019)
    Fusarium mycotoxins are natural contaminants of various commodities representing significant problem worldwide. Since beauvericin (BEA), one of the fusarium toxins, represents a major concern because of its potential toxicity in humans and animal health, and its high presence in feed and food commodities, the present study was carried out to evaluate the effect of BEA on cell viability, proliferation, morphology and gene expression using spermatogonial stem cells (SSCs). First, SSCs were isolated from fresh sheep testis under aseptic technique. Isolated SSCs were cultured for 36 hours at 5% CO2. ...
  • Ismail, Diana (Notre Dame University-Louaize, 2019-02)
    In this thesis, we have restudied a sample chosen by (Lusso & Risaliti, 2016) consisting of a set of 2,153 unique quasars given by two source catalogues: 3XMM-DR5 (Rosen et al., 2016) and DR7 catalogue (Shen et al., 2011). Quasars serve science in two different ways: 1) Understanding accretion physics by studying the physical mechanism occuring between the disk and cloud corona, and 2) they are good cosmological probes in distance estimation reaching redshifts ~ 7 (Mortlock et al., 2011). A physical relation has been observed between the optical-UV disk and the X-ray corona through a log-log ...
  • Najem-Moussa, Wadiha (Notre Dame University-Louaize, 2019-02-02)
    During recent years, the practice of administering antibiotics to animal feed at sub-therapeutic levels has raised concern with consumers because of the apparent increase of antibiotic-resistant bacteria in the human food chain. Researchers have found that probiotics composed of naturally occurring beneficial live microbes such as bacteria (lactobacilli) could be the novel growth promoters. Supplementing poultry diet with probiotics has been found to improve growth performance, feed conversion efficiency, and immune responses, and help in combating enteric pathogens. The aim of this study is ...
  • Hindieh, Pascale (Notre Dame University-Louaize., 2020)
    Sexual activity constitute in the life of the adolescent, a risk-taking and possibly health-compromising behavior. Since unfortunately, knowledge about sexuality is often acquired after sexual activity has begun, sexually transmitted diseases (STDs) should be given high priority in health care and in education. Sexual education is an indispensable need, especially for adolescents, in order to protect them from irresponsible and non-conscious behavior. In the areas of adolescent sexual behavior, sexual education and knowledge, it is imperative and of paramount importance that the health-care ...
  • Nassar, Marc Gerges (Notre Dame University-Louaize., 2020)
    The HPG axis interacts with the Sertoli and Leydig cells to ensure the proper functioning of the male reproductive system. Environmental insults, which are becoming increasingly more common, affect the sensitive male reproductive system in harmful ways. Therefore, the aim of this thesis was to, analyze a network of the paternally imprinted infertility genes shared between the HPG axis and the Sertoli and Leydig cells. With this network in place, we aimed to develop a cell culture system that would allow the evaluation of the effects of certain environmental contaminants such as mycotoxins on ...
  • Nassif, Nathalie (Notre Dame University-Louaize, 2020)
    Chronic moderate alcohol consumption has been implicated in promoting bone health in acyclic (postmenopausal) women via increasing bone mineral density. To our knowledge, no studies investigated the potential effects of ethanol on the bone-specific markers osteocalcin and RANKL which are important in regulating osteoblast - osteoclast activity and bone metabolism. Therefore, the aim of the study was to look into RANKL expression in serum and RANKL and osteocalcin expression in the femoral neck following chronic alcohol consumption of 12% v/v ethanol in water in acyclic C57BL/6 mice. Female ...
  • Maalouf, George Emmanuel (2020)
    Purpose: With the rapid increase in respiratory illnesses and pollution, face masks such as clothe masks, N95 masks, and surgical masks are becoming increasingly more common in everyday life. The recent SARS-CoV-2 outbreak has led to the exponential worldwide use of these masks in everyday activities. However, little is known about the effects of these masks on maximal oxygen consumption during exhaustive exercise. Methods: 11 Athletic individuals and 7 recreational individuals were recruited and took part in the 20 m shuttle run test, also known as the “beep test”, while wearing surgical masks ...
  • Touma, Tina (Notre Dame University-Louaize, 2020)
    One of the clinically major gynecological cancers is endometrial carcinoma that develops from the lining of the uterus. During the past years, different approaches have been developed to treat endometrial carcinoma, among which natural herbal medicine has recently faired as an effective method. The yellow Indian spice known as curcumin has been extolled for its healing powers and has recently been adopted for investigation by the scientific community as a potent anti-cancerous agent. Curcumin possesses anticancerous effects by targeting several important players in cell signaling pathways ...
  • Boukarroum, Rayyan Hamad (Notre Dame University-Louaize, 2020)
    Cement is one of the most fundamentally used material all over the world. Among the many different properties of cement, compressive strength conventionally determined at the age of 28 days remains the most important parameter to assess cement quality. Waiting for 28 days to obtain a test result urges cement manufacturers to set quality parameters higher than the minimum accepted by norms, which means higher unnecessary manufacturing costs. The aim of this study is to assess the performance of cement mortar when nano silica (Nano-SiO2) is used as supplementary cementitious material (SCMs) and ...
  • Mitri, Nadim (Notre Dame University-Louaize, 2020)
    In this study, gold nanoparticles (AuNPs) were synthesized in water and characterized using ultraviolet-visible spectroscopy (UV-Vis), dynamic light scattering (DLS) and Zeta potential analysis. AuNPs were coated with thiol functionalized polyethylene glycol (PEG-SH) and scFvD2B (antibody fragment of D2B mAb) well known to recognize the extracellular epitope of the human prostate specific membrane antigen (hPSMA). In fact, scFvD2B binds PSMA and induces its endocytosis, thereby marking PSMA as a docking site for the delivery of therapeutic agents. AuNPs successful coating was confirmed by DLS ...
  • Ghosn, Marc (Notre Dame University-Louaize, 2020-07)
    An extraction protocol for saponins of Styrax Officinalis plant was adopted, modified and successfully applied. The extract obtained was tested by stabilizing Oil-in-Water emulsions. Ethanol extraction and successful one-step partial purification using AB-8 adsorption column chromatography yielded positive colorimetric (Vanillin – Sulfuric Acid) TLC results. The 3D structure of the four Styrax Officinalis saponins reported in the literature were rendered for the first time, and their partitioning properties exclusively acquired using Marvin Sketch chemical drawing software. 10% w/w Sunflower Oil ...
  • Sahakian, Joseph Ohannes (Notre Dame University-Louaize, 2020-09)
    Ceratitis capitata or the Mediterranean fruit fly (medfly) is a highly invasive and destructive pest due to its tolerance of various climatic and environmental conditions as well as broad host range, including hundreds of fruits and vegetables. Medfly has a great economic impact on fruit production, national market and world trade. The population in Lebanon has been on the rise since 2007 due to several factors including optimal climate and host conditions, insecticide resistance, and negligent regulatory and detection measures during fruit harvest and transportation. Medfly infestation in Lebanon ...
  • Dib, Kevin (Notre Dame University-Louaize, 2020-10)
    In this work, Silver Nanoparticles (AgNPs) were synthesized in water using either polymer assisted chemical reduction synthesis method or green synthesis. The obtained AgNPs were characterized by Dynamic Light Scattering (DLS) and UV-visible spectroscopy (UV-vis), and further tested for antibacterial activity to evaluate their potential use in wound healing. At first polyvinylpyrrolidone (PVP 10 KD) and Low-Molecular Weight Chitosan were used as coating agents during the reduction of silver nitrate with a strong reducing agent sodium borohydride (NaBH4). Our DLS results demonstrated that ...
  • Matar, Rana (Notre Dame University-Louaize, 2020-10)
    Pollution has long been a burden to humanity, and among the most prominent types is plastic pollution. Plastics have been an expedient source for human activity and progress, however its large carbon footprint and harmful effects on animals, humans and habitats outweighs its advantages. Despite recycling efforts, plastic’s non bio-degradability continues to harm the environment. Bioremediation has been the most recent endeavor in managing plastic pollution, where recently discovered microorganisms have shown the capacity to break down different types of plastics. This paper highlights all ...
  • Jerdy, Jouliana (Notre Dame University-Louaize, 2020-12)
    Yerba Mate (Ilex paraguariensis) is a beverage that is highly consumed by certain communities in Lebanon. Several studies have shown the benefits of yerba mate consumption on one's health. Also, Lebanese add to their hot drink some medicinal plants that have been acquired by the society from the Arabian folk medicine. Many studies have been conducted, yet little is known about its effect on the Lebanese health, as they have been consuming it for almost 100 years. Therefore, this study was done to assess the use of yerba mate and medicinal plants. A questionnaire was distributed among 200 local ...
  • Nader, Ingrid (Notre Dame University-Louaize, 2021)
    Candida albicans, is usually a harmless fungus in healthy individuals, but life-threatening when found in large quantities or in inappropriate parts of the body. It developed resistance against the antifungal drugs fluconazole and amphotericin B, used in an abusive way, by adopting different mechanisms. Medicinal plants, which offer a wide variety of secondary metabolites, especially saponins, have been reported for their large biological activities. These phytochemicals are composed of a hydrophobic part (aglycone) and a hydrophilic one (glycone), which, based on their aglycone part, are ...

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